Dovonex

Generic Name: calcipotriene

Calcipotriol is a nonsteroidal antipsoriatic agent, derived from the naturally occurring vitamin D. Calcipotriol exhibits a vitamin D-like effect by competing for the 1,25 (OH)2D3 receptor. Calcipotriol is as potent as 1,25 (OH)2D3, the naturally occurring active form of vitamin D, in regulating cell proliferation and cell differentiation, but much less active than 1,25 (OH)2D3 in its effect on calcium metabolism. Calcipotriol induces differentiation and suppresses proliferation (without any evidence of a cytotoxic effect) of keratinocytes, thus reversing the abnormal keratinocyte changes in psoriasis. The therapeutic goal envisaged with calcipotriol is thus a normalization of epidermal growth.

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Dovonex Uses

Dovonex Cream is indicated for the treatment of plaque psoriasis.

How Taken Dovonex

This medication is usually applied twice daily (in the morning and evening) to the affected areas of the skin. If needed, it may be applied once daily for maintenance treatment. Once an appropriate improvement has occurred, treatment may be stopped. When used in combination with other psoriasis medications, it is usually applied once daily, at a different time of day than the other medication. It is important to use this medication exactly as prescribed by your doctor.

The maximum weekly adult dose for the cream or ointment is 100 g (5 mg of calcipotriol). Maximum doses for children are calculated based on body surface area and age. When the cream, ointment, or scalp solution are used together, the weekly maximum dose is based on the total amount of calcipotriol in each product, for a maximum weekly dose of 5 mg calcipotriol for adults.

Dovonex Warnings/Precautions

Use of Dovonex Cream may cause transient irritation of both lesions and surrounding uninvolved skin. If irritation develops, you should discontinue using Dovonex Cream. Do not use this medication for any disorder other than that for which it was prescribed.

Dovonex Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Dovonex Possible Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• burning, dry, irritated, peeling, or red skin
• itching, redness, and swelling of the skin
• face and scalp irritation (when the medication is transferred from another part of the body)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Dovonex Storage

Store at controlled room temperature 15°C - 25°C (59°F - 77°F). Do not freeze.

Dovonex Overdose

Topically applied Dovonex Cream can be absorbed in sufficient amounts to produce systemic effects. If an overdose is suspected, discontinue Donovex Cream and seek medical attention.

Dovonex More Information

This medication is to be used only as directed by your physician. It is for external use only. Avoid contact with the face or eyes. As with any topical medication, you should wash your hands after application. Report to your physician any signs of adverse reactions.

Dovonex Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.